Other complications of IM injections include local induration, erythema, hematoma, persistent bleeding, and ultimately, drug discontinuation. Infection is a risk with any parenteral injection because of the risk of bacteria being introduced into the tissue (2, 4–6), which in turn can lead to abscesses and infections in the skin or soft tissue. IM injections, therefore, are best performed by trained personnel who are familiar with anatomical landmarks, which may be difficult to identify in obese or emaciated patients. Because of the needle length and bore size required, IM injections are painful and can temporarily result in limited mobility, an issue of particular concern in older patients (2). There is a possibility of hitting a nerve or blood vessel, leading to muscle contractures and nerve injury (3). Because of the distance from the skin surface into a muscle, IM injections require a relatively long needle (1–2 in.). Volumes of 2–5 mL can be administered, and this route is particularly suited for drugs that are not readily soluble, as a sustained depot action is possible (2, 3). IM injections are given deep into skeletal muscle and usually involve the gluteal, deltoid, rectus femoris, or vastus lateralis muscles. When therapeutic regimens require injection volumes in excess of 1 mL, intramuscular (IM) injections are generally chosen. ![]() This entire process occupies both space in an office and specialized nursing time (1). IV drugs are administered by trained medical personnel in a hospital or physician's office and, because of the rapid effects achieved, patients are typically observed for undesired side effects following injection. Direct IV access also carries a risk of systemic infection. IV dosing requires the skilled insertion of a needle or catheter directly into a vein, a process that can be challenging, especially in certain patient types such as obese, palliative-care, and neonate patients. IV dosing is also typical when administering irritating agents such as cytotoxics that would otherwise cause tissue damage and pain if given by alternative routes. IV injections are given either as a 1-to-2-min-bolus or an infusion with a longer duration to facilitate administering precise doses in a controlled manner or in providing a rapid response. For many drugs, including biologics and anticancer agents, the traditional route of administration is intravenous (IV). Therapeutic agents can be introduced into the body by several routes of administration with each having specific advantages and disadvantages (see Table I). Intravenous, intramuscular, and subcutaneous delivery Using a recombinant DNA-derived hyaluronidase enzyme is an approach for possibly changing dosing regimens and bioavailability of several types of agents, including biologics. Strategies for overcoming this problem are crucial to widening the scope of drugs that may be given subcutaneously. If you want to spend some $ to get isk, this is the best deal on the block by a huge margin.Although subcutaneous (SC) delivery is the preferred way to administer an injected therapeutic, SC injections are limited in the amount of drug substance that can be delivered. Regardless of exactly how you figure things, though, all of these packs are WAY better than just buying even the top end plex pack. ( edit: assuming you are allowed to apply both, the $7.50 + $50 packs work out to paying $12.50 for 8.08 bil worth of stuff, for a whopping 647 mil/$ plus skins!) ![]() ![]() After that, the 50$ pack is a great bang for your buck, with the 25$ pack the least worthwhile. If you're already paying a sub, then the $7.50 pack is a no-brainer - it's basically free money, absolutely no reason not to buy it. Those two packs also are the ones with skins, though the value for those is uncertain. you're not subbing with $ and so value omega time at the plex rate), the packs are all fairly similar with a slight edge towards the $7.50 and $50 packs. 'Already was going to sub' value: 7.74 bil for $16.25 -> 584 mil/$ 'Already was going to sub' value: 4.12 bil for $13.75 -> 300 mil/$ 'Already was going to sub' value: value of omega time exceeds pack price they're basically paying you $3.75 to give you 110 plex and a few skins. Subscription costs assume a 6 month subscription.) (All prices jita buy prices from as of post time. Breakdown as follows:ġ00$ plex pack is 2860 plex = 8.92 bil, which works out to 89.2 million isk per dollar.ġ month omega time = $11.25 or 500 plex = 1.56 bil Cross-posting from the other thread since it seems to have vanished for some reason:Īs expected, these packs are pretty darn good deals.
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